Research Progress of Mesenchymal-Epithelial Transition in Female Reproductive System

doi:10.12280/gjszjk.20200339

Abstract

Abstract:

Mesenchymal epithelial transition (MET) is a biological characteristic of the transformation between mesenchymal cells and epithelial cells. It is the basis of many biological processes in the human body. It also plays a key role in the formation and development of the female reproductive system. MET begins at the early stage of embryo development, which is involved in the formation of multiple organs and tissues. In addition, MET not only helps the physiological regeneration of endometrial epithelial cells and the decidualization to regulate the adhesion and implantation of embryos, but also plays an important role in the pathological process of reproductive diseases such as endometriosis and tumors. This article reviews the research progress related to MET in order to provide ideas and directions for the research on the structure and function of female reproductive system and the prevention and treatment of reproduction-related diseases.

Key words: Mesenchymal-epithelial transition, Epithelial-mesenchymal transition, Infertility, female, Endometrium, Embryonic development, Endometriosis, Neoplasms

WANG Bin, GAO Ming-xia, SHEN Hao-fei, WANG Yi-qing, ZHANG Xue-hong. Research Progress of Mesenchymal-Epithelial Transition in Female Reproductive System[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(1): 44-48.

References 35

[1]	温思茜, 宋亚丽, 刘婧, 等. 上皮-间质转化与女性生殖系统发育、功能及疾病[J]. 国际生殖健康/计划生育杂志, 2019,38(3):236-239. doi: 10.3969/j.issn.1674-1889.2019.03.014.
[2]	Owusu-Akyaw A, Krishnamoorthy K, Goldsmith LT, et al. The role of mesenchymal-epithelial transition in endometrial function[J]. Hum Reprod Update, 2019,25(1):114-133. doi: 10.1093/humupd/dmy035.
[3]	Bizzarri M, Cucina A, Proietti S. Tumor Reversion: Mesenchymal-Epithelial Transition as a Critical Step in Managing the Tumor-Microenvironment Cross-Talk[J]. Curr Pharm Des, 2017,23(32):4705-4715. doi: 10.2174/1381612823666170609082757.
[4]	和鹏飞, 魏凯, 谢院生. 间充质-上皮转化的生物学作用及其影响因素[J]. 中华肾病研究电子杂志, 2016,5(6):281-284. doi: 10.3877/cma.j.issn.2095-3216.2016.06.010.
[5]	Guo F, Parker Kerrigan BC, Yang D, et al. Post-transcriptional regulatory network of epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions[J]. J Hematol Oncol, 2014,7:19. doi: 10.1186/1756-8722-7-19.
[6]	Pei D, Shu X, Gassama-Diagne A, et al. Mesenchymal-epithelial transition in development and reprogramming[J]. Nat Cell Biol, 2019,21(1):44-53. doi: 10.1038/s41556-018-0195-z.
[7]	Rodriguez-Boulan E, Macara IG. Organization and execution of the epithelial polarity programme[J]. Nat Rev Mol Cell Biol, 2014,15(4):225-242. doi: 10.1038/nrm3775.
[8]	Shu X, Pei D. The function and regulation of mesenchymal-to-epithelial transition in somatic cell reprogramming[J]. Curr Opin Genet Dev, 2014,28:32-37. doi: 10.1016/j.gde.2014.08.005.
[9]	Wu J, Ocampo A, Belmonte J. Cellular Metabolism and Induced Pluripotency[J]. Cell, 2016,166(6):1371-1385. doi: 10.1016/j.cell.2016.08.008.
[10]	Villarejo A, Cortés-Cabrera A, Molina-Ortíz P, et al. Differential role of Snail1 and Snail2 zinc fingers in E-cadherin repression and epithelial to mesenchymal transition[J]. J Biol Chem, 2014,289(2):930-941. doi: 10.1074/jbc.M113.528026.
[11]	Xiong M, Jiang L, Zhou Y, et al. The miR-200 family regulates TGF-β1-induced renal tubular epithelial to mesenchymal transition through Smad pathway by targeting ZEB1 and ZEB2 expression[J]. Am J Physiol Renal Physiol, 2012,302(3):F369-F379. doi: 10.1152/ajprenal.00268.
[12]	Huang CC, Orvis GD, Wang Y, et al. Stromal-to-epithelial transition during postpartum endometrial regeneration[J]. PLoS One, 2012,7(8):e44285. doi: 10.1371/journal.pone.0044285.
[13]	Patterson AL, Zhang L, Arango NA, et al. Mesenchymal-to-epithelial transition contributes to endometrial regeneration following natural and artificial decidualization[J]. Stem Cells Dev, 2013,22(6):964-974. doi: 10.1089/scd.2012.0435.
[14]	Cousins FL, Murray A, Esnal A, et al. Evidence from a mouse model that epithelial cell migration and mesenchymal-epithelial transition contribute to rapid restoration of uterine tissue integrity during menstruation[J]. PLoS One, 2014,9(1):e86378. doi: 10.1371/journal.pone.0086378.
[15]	Zhang XH, Liang X, Liang XH, et al. The mesenchymal-epithelial transition during in vitro decidualization[J]. Reprod Sci, 2013,20(4):354-360. doi: 10.1177/1933719112472738.
[16]	Ramathal CY, Bagchi IC, Taylor RN, et al. Endometrial decidualization: of mice and men[J]. Semin Reprod Med, 2010,28(1):17-26. doi: 10.1055/s-0029-1242989.
[17]	Yu L, Hu R, Sullivan C, et al. MFGE8 regulates TGF-β-induced epithelial mesenchymal transition in endometrial epithelial cells in vitro[J]. Reproduction, 2016,152(3):225-233. doi: 10.1530/REP-15-0585.
[18]	Al Khatib AM, Stepan AE, Margaritescu C, et al. E-cadherin and Snail Immunoexpression in Colorectal Adenocarcinomas[J]. Curr Health Sci J, 2019,45(2):204-209. doi: 10.12865/CHSJ.45.02.12.
[19]	Yu J, Berga SL, Johnston-MacAnanny EB, et al. Endometrial Stromal Decidualization Responds Reversibly to Hormone Stimulation and Withdrawal[J]. Endocrinology, 2016,157(6):2432-2446. doi: 10.1210/en.2015-1942.
[20]	Wu M, Yang L, Liu S, et al. Differentiation potential of human embryonic mesenchymal stem cells for skin-related tissue[J]. Br J Dermatol, 2006,155(2):282-291. doi: 10.1111/j.1365-2133.2006.07357.x.
[21]	Orvis GD, Behringer RR. Cellular mechanisms of Müllerian duct formation in the mouse[J]. Dev Biol, 2007,306(2):493-504. doi: 10.1016/j.ydbio.2007.03.027.
[22]	Soundararajan R, Paranjape AN, Barsan V, et al. A novel embryonic plasticity gene signature that predicts metastatic competence and clinical outcome[J]. Sci Rep, 2015,5:11766. doi: 10.1038/srep11766.
[23]	Lin T, Ambasudhan R, Yuan X, et al. A chemical platform for improved induction of human iPSCs[J]. Nat Methods, 2009,6(11):805-808. doi: 10.1038/nmeth.1393.
[24]	Wang Y, Mah N, Prigione A, et al. A transcriptional roadmap to the induction of pluripotency in somatic cells[J]. Stem Cell Rev Rep, 2010,6(2):282-296. doi: 10.1007/s12015-010-9137-2.
[25]	Proestling K, Birner P, Gamperl S, et al. Enhanced epithelial to mesenchymal transition (EMT) and upregulated MYC in ectopic lesions contribute independently to endometriosis[J]. Reprod Biol Endocrinol, 2015,13:75. doi: 10.1186/s12958-015-0063-7.
[26]	竺天虹, 张信美. 上皮间充质转化介导子宫内膜异位症发生发展的研究进展[J]. 浙江大学学报(医学版), 2016,45(4):439-445. doi: 10.3785/j.issn.1008-9292.2016.07.17.
[27]	牛亚南, 庄梦斐, 曹阳, 等. 间质-上皮转化参与子宫内膜异位症模型大鼠包囊形成[J]. 中华生殖与避孕杂志, 2018,38(9):748-756. doi: 10.3760/cma.j.issn.2096-2916.2018.09.009.
[28]	Matsuzaki S, Darcha C. Epithelial to mesenchymal transition-like and mesenchymal to epithelial transition-like processes might be involved in the pathogenesis of pelvic endometriosis[J]. Hum Reprod, 2012,27(3):712-721. doi: 10.1093/humrep/der442.
[29]	Kim Y, Bang SS, Jee S, et al. Prevalence and Clinicopathological Significance of MET Overexpression and Gene Amplification in Patients with Gallbladder Carcinoma[J]. Cancer Res Treat, 2020,52(2):481-491. doi: 10.4143/crt.2019.370.
[30]	Behl T, Kumar C, Makkar R, et al. Intercalating the Role of MicroRNAs in Cancer: As Enemy or Protector[J]. Asian Pac J Cancer Prev, 2020,21(3):593-598. doi: 10.31557/APJCP.2020.21.3.593.
[31]	Faddaoui A, Bachvarova M, Plante M, et al. The mannose receptor LY75 (DEC205/CD205) modulates cellular phenotype and metastatic potential of ovarian cancer cells[J]. Oncotarget, 2016,7(12):14125-14142. doi: 10.18632/oncotarget.7288.
[32]	Kim J, Coffey DM, Creighton CJ, et al. High-grade serous ovarian cancer arises from fallopian tube in a mouse model[J]. Proc Natl Acad Sci U S A, 2012,109(10):3921-3926. doi: 10.1073/pnas.1117135109.
[33]	Daikoku T, Jackson L, Besnard V, et al. Cell-specific conditional deletion of Pten in the uterus results in differential phenotypes[J]. Gynecol Oncol, 2011,122(2):424-429. doi: 10.1016/j.ygyno.2011.04.022.
[34]	Zheng Q, Gao J, Yin P, et al. CD155 contributes to the mesenchymal phenotype of triple-negative breast cancer[J]. Cancer Sci, 2020,111(2):383-394. doi: 10.1111/cas.14276.
[35]	Nihan Kilinc A, Sugiyama N, Reddy Kalathur RK, et al. Histone deacetylases, Mbd3/NuRD, and Tet2 hydroxylase are crucial regulators of epithelial-mesenchymal plasticity and tumor metastasis[J]. Oncogene, 2020,39(7):1498-1513. doi: 10.1038/s41388-019-1081-2.