Precision Medicine in the Field of Assisted Reproduction

doi:10.12280/gjszjk.20200412

Abstract

Abstract:

Precision medicine and its advanced technologies have promoted the development of reproductive medicine. The high-throughput sequencing, genome-wide association studies (GWAS), proteomics technology have been successfully used in the etiological diagnosis of infertility, the detection of genetic disease and the pre-implantation genetic testing (PGT) in clinical practice, and the single-celled whole genome amplification (eWGA), biological big data analysis and so on have been also applied in the research of human gamete and early embryo development in recent years. For example, 11 loci and 17 single nucleotide polymorphisms (SNPs) were identified by GWAS, which are strongly correlated with PCOS. When eWGA is applied to PGT, the whole genome information of the egg itself can be deduced by analyzing a single cell obtained from the pre-implantation embryo, so as to reduce the birth with congenital genetic defects and to reduce the iatrogenic risk of assisted reproduction. The artificial intelligence-assisted (AI) method for oocyte or embryo selection during in vitro fertilization-embryo transfer are showing increasing its advantages. This paper reviews the application of precision medicine in assisted reproduction.

Key words: Precision medicine, Reproductive techniques,assisted, High-throughput nucleotide sequencing, Infertility, Genomics, Artificial intelligence

LANG Peng, SHI Xiao-dan, ZHANG Jun-qiang. Precision Medicine in the Field of Assisted Reproduction[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(2): 121-125.

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