Research Progress on Endometrial Immune Factors of Recurrent Implantation Failure

doi:10.12280/gjszjk.20210432

Abstract

Abstract:

Embryo recurrent implantation failure (RIF) is an important limiting factor for the clinical success rate of in vitro fertilization and embryo transfer (IVF-ET), and endometrial immunity-related factors have an important influence on the occurrence of RIF. A variety of immune cells in endometrium, including natural killer cells (NK cells), macrophages (Mφ), dendritic cells (DC) and T cells, play an important role in the regulation of endometrial receptivity and embryo implantation. Many of immune-related cytokines in endometrium, including IL-6, IL-10, IL-15, IL-17, TNF-α, IFN-γ and NF-κB, also contribute to embryo adhesion, trophoblast invasion, vascular remodeling and immune tolerance, which determine embryo implantation and development. Endometrial immune imbalance plays an important role in the pathological mechanism of RIF, but there is no high-level and evidence-based medical evidence for whether patients with RIF should be treated with immunotherapy.

Key words: Embryo implantation, Fertilization in vitro, Embryo transfer, Endometrium, Immunocompetence

ZANG Zhao-wen, DAI Cai-feng, GAO Jing-yue, DENG Xiao-hui. Research Progress on Endometrial Immune Factors of Recurrent Implantation Failure[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(1): 68-73.

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