Application of Mononuclear Cells in the Treatment of Reproductive System Diseases

doi:10.12280/gjszjk.20220034

Abstract

Abstract:

Mononuclear cells (MNCs) are a cell population of a variety of immune cells and pluripotent stem/progenitor cells. According to the source, they are mainly divided into umbilical cord blood mononuclear cells, bone marrow mononuclear cells and peripheral blood mononuclear cells. MNCs can inhibit apoptosis, and promote the differentiation and proliferation of stem cells in the damaged tissues. MNCs can also promote angiogenesis, and regulate the local immune microenvironment in vivo. The mechanisms of action may be related to homing, secretion and paracrine effects. The application researches of MNCs in the treatment of reproductive system diseases mainly involve premature ovarian failure, intrauterine adhesions and repeated implantation failure. The types of MNCs, tranplantation approaches and the development of clinical trials involved in studies are different. Exosomes, biological scaffolds and gene therapy are expected to become new exploration points for MNCs to treat female reproductive system diseases. However, there are still problems that cannot be ignored in the application of MNCs, including the effect of transplantation route and concentration on the treatment.

Key words: Cell transplantation, Cell- and tissue-based therapy, Female urogenital diseases, Treatment outcome, Mononuclear cells

GAO Jing-yue, YU Xuan, ZANG Zhao-wen, DENG Xiao-hui. Application of Mononuclear Cells in the Treatment of Reproductive System Diseases[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(3): 240-244.

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