Research Progress on Anti-Müllerian Hormone and Inhibin B in the Transgenerational Effects of Polycystic Ovary Syndrome

doi:10.12280/gjszjk.20250498

Abstract

Abstract:

Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting the female reproductive system. The prolonged exposure to elevated androgen may have transgenerational consequences on the reproductive, metabolic, and psychobehavioral characteristics of offspring. Anti-Müllerian hormone (AMH) and inhibin B (INHB), two of the key reproductive endocrine markers, are implicated in the PCOS pathogenesis and transgenerational effect, as well as the diagnosis of PCOS, because AMH and INHB influence reproductive development, metabolic function, and mental development in the offspring of PCOS. Future studies should clarify the mechanism of action, with the goal of providing a theoretical basis and practical strategies for the early identification, prevention, and management of PCOS-related transgenerational effects. We review the biological features of AMH and INHB, and examine their influence on thire offspring of PCOS, aiming to highlight their potential as predictive biomarkers for disease risk in these offspring.

Key words: Polycystic ovary syndrome, Anti-Mullerian hormone, Inhibins, Transgenerational effects, Offspring health

LIN Tuo, NING Shu-ting, HUA Ying, YE Li-hua, MA Hong-xia. Research Progress on Anti-Müllerian Hormone and Inhibin B in the Transgenerational Effects of Polycystic Ovary Syndrome[J]. Journal of International Reproductive Health/Family Planning, 2026, 45(1): 66-70.

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