Abstract: The cystic fibrosis transmembrane conductance regulator（ＣＦＴＲ）, expressed in epithelial cells of a wide variety of tissues, is a cAMP-dependent chloride channel. It mediated secretion and transportion of anions and water at epithelial cells. Mutations in the gene encoding CFTR cause cystic fribrosis, with congenital absence of the vas deferens and spermatogenesis failure in male patients and reduced fertility in female patients. CFTR is expressed in a wide variety of epithelial cells in male and female reproductive tracts with an important role in reproductive health. In this paper, we discussed the physiological role of CFTR in reproduction, such as spermatogenesis, sperm capacitation, implantation and early embryo development.

Key words: Cystic fibrosis transmembrane conductance regulator, Epithelial cells, Infertility, Sperm capacitation, Genes