Abstract: Primary ovarian failure（ＰＯＦ） is a common cause of female infertility， with the incidence ascending year by year. The known causes of POF include chromosomal defects， autoimmune diseases，exposure to radiation or chemotherapy， surgical procedures， and some drugs. Even so， the majority of patients could have no etiological evidence. Inhibin and Anti Mullerian Hormone could be used as marks for presymptomatic diagnosis of POF. The diagnosis is based on the amenorrhea before age 40 associated with the elevated FSH levels in the menopausal range. Management essentially involves hormone replacement and infertility treatment. Oocyte donation is the only proven means for infertility treatment of POF.

Key words: Ovarian failure, premature, Diagnosis, Forecasting, Therapy, Hormone replacement therapy, Reproductive techniques, assisted