Journal of International Reproductive Health/Family Planning

Journal of International Reproductive Health/Family Planning ›› 2013, Vol. 32 ›› Issue (1): 50-54.

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Effects of Di（2-ethylhexyl） phthalate （DEHP） on Mammalian Reproductive System: A Review

ZHOU Wan-ge，WANG Tong-fei，ZHOU Ren，DING Zhi-de   

  1. Department of Clinical Medicine（ZHOU Wan-ge，WANG Tong-fei，ZHOU Ren），Department of Human Histology and Embryology（DING Zhi-de），School of Medicine，Shanghai Jiao Tong University，Shanghai 200025，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-01-15 Online:2013-01-15
  • Contact: DING Zhi-de

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Abstract: DEHPs，chemicals contained abundantly in many industrial products，had severe adverse effects on mammalian reproductive system involved in both male and female development. The development of mammalian reproductive system is related to a variety of hormones and the regulation of genes. DEHPs could interfer the key steps of hormone metabolism or gene expression. This review focused on the toxic effects of DEHP，and its mechanism，which is important for clinic to prevent，diagnose and treat the diseases of reproductive system.

Key words: Mammals, Diethylhexyl phthalate, Male urogenital diseases, Female urogenital diseases