Abstract: HCV infection attracted extensive attention, especially HCV infection in the perinatal period. HCV-RNA can be detected in semen and sperm even at low level. Patients with HCV infection had the impaired sperm parameters, including routine analysis and biofunctional parameters, which suggested that HCV infection impacted male fertility. Those HCV couples can obtain their pregnancies by assisted reproductive technology （ART）, and the risk of HCV transmission in perinatal period can be reduced, while health of their descendents can not be ignored.

Key words: Hepacivirus, Spermatozoa, Reproductive techniques, assisted, Pregnancy outcome, Health status