Abstract: The developmental competence of oocyte is gradually accumulated through folliculogenesis，during which the tight communication between cumulus cells （CCs） and oocyte is established while follicle fulid（FF） maintains an optimal micro-environment for oocyte maturation. So，it is generally accepted that oocyte competence can be evaluated through biological functions of CCs and molecular components of FF within the ovarian follicle. CCs play an important role by providing metabolic nutrients for the oocyte such as pyruvic，alanine，cholesterol and so on，meanwhile CCs are involved in oocyte maturation，ovulation as well as fertilization process. Metabolic factors，hormones，reactive oxygen species and some cytokines in FF are closely linked to oocyte growth. Herein we reviewed the biomarkers of oocyte quality and embryo developmental competence in CCs and FF.

Key words: Oocytes, Biological markers, Cumulus cells, Follicular fluid, Embryonic development