Abstract: Epigenetic changes are commonly found in those patients with server oligozoospermic and non-obstructive azoospermia. It was found that there was correlationship between the increased DNA methylationes of MTHFR, PAX8, NTF3, SFN, HRAS, JHM2DA, and the abnormal seminal parameters of those infertile patients. It is very important to regulate accurately the methylation and demethylation of those genes for individual development. Any tiny abnormality in DNA methylation could be related to many diseases, including male infertility. In this review, we explored some epigenetic pathogenesis of male infertility by introducing the normal DNA methylation of male germ cell and discussing the relationship between abnormal DNA methylation and male infertility.

Key words: Epigenesis, genetic, DNA methylation, Infertility, male, Reproductive techniques, assisted, Epigenetics