Abstract: Objective：To explore the application of serum pro- B-type natriuretic peptide (PRO-BNP) in pre-eclampsia patients as a potential predictor of maternal and fetal outcomes. Methods: A total of 111 pre-eclampsia women were enrolled in this retrospective study. The level of serum PRO-BNP was measured by immunofluorescence. According to the levels of PRO-BNP, patients were divided into two groups: the normal group (n=85) and the increased group (n=26). The differences of pregnant outcomes were compared between the two groups. Results: The increased group had the lower rate of the expectant treatment (7.7% vs. 36.5%, χ2＝7.893，P=0.005) and the higher incidences of proteinuria and pleural effusion when compared with the normal group (both P＜0.05). However, there were no significant differences in the fetal distress, the rate of premature infant, the newborn treatment transferred to pediatric department, the body mass of newborn and the Apgar score between the two groups (all P＞0.05). Conclusions: The level of serum PRO-BNP was related to the severity of organ injury in those pre-eclampsia women. However, PRO-BNP could not be a predictor of the newborn prognosis.

Key words: Pre-eclampsia, Retrospective studies, Prognosis, Pro B-type natriuretic peptide