Abstract: Ovarian cancer is a reproductive system malignant tumor with the highest mortality, and the main treatment of ovarian cancer is the surgery to cut out tumor tissues following with the auxiliary chemotherapy of taxol. Although most of the patients with ovarian cancer after operation are sensitive to the initial chemotherapy, the prognosis is poor due to their chemotherapy resistance. In recent years, exosome as a way of the material and information exchange between the cells has been a research hotspot. The exosome containing a variety of biological active substances are distributed in various body fluids. More and more studies showed that exosome was participated in many physiological procedures such as antigen presenting, immune response and tissue damage repair, and the occurrence and development of tumor such as tumor microenvironment. In addition, many studies have shown that exosomes could play an important role in the regulation of the chemotherapy resistance of ovarian cancer. Exosomes may be developed as a new therapy target for blocking the chemotherapy resistance and improving the prognosis of ovarian cancer.

Key words: Exosomes, Neoplasms, Ovarian neoplasms, Chemotherapy resistance, Drug resistance, neoplasm, MicroRNAs