Abstract: Preeclampsia (PE) is one of the most serious complications of pregnancy, and there is no effective treatment at present. Exosomes interact with recipient cells and pass proteins, lipids and RNA to these recipient cells. Placental exosomes, as a kind of specific exosomes during pregnancy, play an important role in maintaining normal pregnancy. It is necessary to study the effect of placental exosomes and mechanism in pathological pregnancy. In this article, we review the recent PE-related literatures and summarize the possible roles of placental exosomes in normal pregnancy and the pathogenesis of PE, including the quantity and content feature of placental exosomes, the maternal immune tolerance and related pathways. It is demonstrated that placental exosomes can contribute to the pathogenesis of PE by multiple signaling pathways and immune-mediated mechanisms. The blood-borne biomarkers and microRNAs from placental exosomes could be developed as the biomarkers of PE. We discuss the possible roles of placental exosomes in the early detection and treatment of PE, in order to provide some reference for future research and treatment of PE.

Key words: Exosomes；, Pre-eclampsia；, Placenta；, Biomarkers；, MicroRNAs