Research Progress on the Function of MicroRNA in Decidualization

doi:10.12280/gjszjk.20210363

Abstract

Abstract:

Decidualization is the process of morphological and functional changes of the endometrium from the secretory period to embryo implantation after ovulation. It is very important for the establishment and maintenance of pregnancy and the cyclical changes of endometrium. The transformation of endometrial stromal cell is most important, which is driven by progesterone and cAMP signals and is accompanied by changes in the expressions of a series of marker molecules. MicroRNAs (miRNAs) play an extensive role in the post transcriptional regulation. A large number of studies have shown that miRNAs are involved in the regulation of decidualization related genes, such as IGFBP1, PRL, KLF12 and HOXA10. This article summarizes the role of miRNA synthesis related enzymes and miRNAs in the process of decidualization, which provides more information for the study of decidualization and related diseases such as repeated implantation failure, endometriosis, preeclampsia and other female diseases.

Key words: MicroRNAs, Decidua, Endometrium, Menstrual cycle, Embryo implantation, Endometrial stromal cells

LI Hong-wanyu, YANG Jie-qiong, ZHANG Cong. Research Progress on the Function of MicroRNA in Decidualization[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(6): 476-480.

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