In Vitro Activation of Primordial Follicles in Patients with Primary Ovarian Insufficiency

doi:10.12280/gjszjk.20210343

Abstract

Abstract:

Primary ovarian insufficiency (POI) is one of the important causes of female infertility. At present, the main treatment to realize fertility is the egg donation. However, due to egg source and ethical problems, patients need to face many difficulties. The development of in vitro follicular activation technology brings new treatment ideas for the treatment of POI. The hippopotamus signaling pathway, phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway, mammalian target of rapamycin complex 1 (mTORC1) signaling pathway and other follicle development-related signaling pathways can be in vitro activated by pharmacological or non-pharmacological means, to promote primordial follicle development. The ovarian tissue containing primordial follicles will be subsequently implanted back into the patient, and patients ultimately may achieve the fertility goal. We review the research progress of IVA of primordial follicles in patients with POI, so as to provide reference for the clinical treatment strategy of POI.

Key words: Primary ovarian insufficiency, Ovarian follicle, Signal transduction, Infertility, In vitro oocyte maturation techniques, In vitro activation

SONG Wen-guang, FU Hao, GUO Min, HU Chun-xiu. In Vitro Activation of Primordial Follicles in Patients with Primary Ovarian Insufficiency[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(6): 486-489.

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