Advances in RFRP-3 Regulates Reproduction in the Female Mammal

doi:10.12280/gjszjk.20210325

Abstract

Abstract:

Reproduction of female mammals is regulated by a complex network of the hypothalamic-pituitary-ovarian (HPO) axis integrated with peripheral and central stimulators. RFamide-related peptide 3 (RFRP-3), a kind of mammalian hypothalamic neuropeptide, is a inhibitor of HPO axis in the mammalian hypothalamus. RFRP-3 plays major physiological roles by binding to its specific receptor, G protein-coupled receptor 147 (GPR147). It can synergistically affect mating behavior and reproductive activities of mammals with other neuropeptides. In addition, RFRP-3 can regulate hypothalamus energy homeostasis signal. However, there is no consensus on the main determinants of endogenous role of RFRP-3 in metabolic homeostasis and reproductive activity in female mammals. In this paper, we review the effects of RFRP-3 on energy balance, stress regulation and reproductive function in female mammals, in order to provide new insights into the mechanisms and therapeutic interventions of reproductive and metabolic diseases.

Key words: Neuropeptides, Gonadotropins,pituitary, Gonadotropin-releasing hormone, Gonadal steroid hormones, Reproductive, Stress,physiological, Energy metabolism, RFamide-related peptide 3

LI Yang, YANG Hong-yan. Advances in RFRP-3 Regulates Reproduction in the Female Mammal[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(1): 52-56.

References 33

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