Research Progress of Transform Growth Factor-β1 in Intrauterine Adhesions

doi:10.12280/gjszjk.20220466

Abstract

Abstract:

Intrauterine adhesion (IUA) is a disease of the endometrial fibrosis caused by the damaged endometrial basal layer. The common clinical manifestations of IUA are menstrual change，infertility and pregnancy failure and repeated embryo implantation failure. Therefore, IUA seriously affects the reproductive health of women of reproductive age. The evolution of IUA is more complex and variable, which is controlled by a multifactorial and multilevel combination. Transform growth factor-β1 (TGF-β1) as a cytokine plays an important role in regulating cell growth, differentiation and apoptosis. TGF-β1 is involved in the pathological progression of many human diseases. It is believed that TGF-β1 is closely related to the tissue fibrosis, and that its overexpression promotes the endometrial fibrosis and aggravates the degree of IUA. In this article, we describe the research progress of TGF-β1 and its related pathways in IUA.

Key words: Transforming growth factor beta1, Uterine diseases, Fibrosis, Inflammation, Intrauterine adhesions, Pathogenesis

LI Guang-can, ZHAI Chao, ZHANG Xiao-xuan, REN Chun-e. Research Progress of Transform Growth Factor-β1 in Intrauterine Adhesions[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(1): 83-88.

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