Research Progress on the Mechanisms of Oocyte Aging

doi:10.12280/gjszjk.20240519

Abstract

Abstract:

Ovarian aging is the beginning of female aging, which not only relates to women's reproductive health but also serves as an important influencing factor of the low fertility rate in the nowadays society. Currently, the mechanisms of female reproductive aging have been extensively studied from multiple levels, including cellular, molecular, systemic and individual levels. This review summarizes various biological mechanisms involved in oocyte aging, such as mitochondrial function, chromosomes, oxidative stress, energy metabolism and immune factors. It also explores the progress of targeted therapies for female reproductive aging, aiming to provide important insights for preventing premature ovarian failure and even delaying reproductive aging.

Key words: Oocytes, Aging, Chromosomes, Mitochondria, Oxidative stress, Energy metabolism, Immune factors

ZHANG Jiang-lin, YUAN Hai-ning, ZHANG Yun-jie, LI Heng-bing, YUAN Li-hua, SUN Zhen-gao. Research Progress on the Mechanisms of Oocyte Aging[J]. Journal of International Reproductive Health/Family Planning, 2025, 44(2): 144-149.

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