Application of Oocyte Cryopreservation in Patients with Iatrogenic Diminished Ovarian Reserve

doi:10.12280/gjszjk.20230306

Abstract

Abstract:

Since the first successful use of oocyte cryopreservation and resuscitation, to obtain twin pregnancies, in 1986, oocyte cryopreservation has gradually become an intervention measure for iatrogenic ovarian dysfunction. In recent years, the number of patients with diminished ovarian reserve (DOR) has shown an increasing trend, and the preservation of their fertility is receiving increasing attention. The iatrogenic influencing factors of DOR mainly include reproductive system surgery, tumor radiotherapy and chemotherapy, etc. Oocyte cryopreservation is a first-line treatment option for fertility preservation, and its safety, applicability, utilization rate, and egg donation treatment in the clinical application of iatrogenic DOR patients have been confirmed by clinical data and relevant literature. However, the issues related to the timing of oocyte cryopreservation, limitations of clinical application and ethical policies cannot be ignored. Oocyte cryopreservation is of great significance for improving the pregnancy outcomes of unmarried patients with iatrogenic DOR and the reproductive autonomy of married patients. After clarifying the iatrogenic influencing factors of DOR, it is recommended to seek consultation from multiple disciplines such as oncology, gynecology and reproductive health as soon as possible to develop the personalized oocyte cryopreservation plans.

Key words: Oocytes, Vitrification freezing, Fertility, Neoplasms, Gynecologic surgical procedures, Reproductive techniques, assisted, Diminished ovarian reserve

YE Ming-zhu, ZHENG Jie, LI Jie-peng, XU Li-xin. Application of Oocyte Cryopreservation in Patients with Iatrogenic Diminished Ovarian Reserve[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(6): 498-502.

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