Abstract: Endometriosis (EMs) is a common gynecological disease. The incidence of EMs in reproductive women is about 10% to 15%, and up to 50% of EMs patients are infertile. Gonadotropin releasing hormone agonists (GnRHa), commonly used in the treatment of EMs, act on the hypothalamus pituitary system and endometrium through different mechanisms. Most reports confirmed the efficacy of GnRHa treatment after conservative surgery in increasing the pregnancy rate and decreasing relapse rate in EMs patients with infertility. GnRHa can also play a certain role in preventing the recurrence of ovarian endometriosis and alleviating the pain of deep invasive endometriosis. GnRHa and hormonal reverse therapy are often applied to improve the life quality of patients with adolescent endometriosis. The prolonged GnRHa protocol don't affect the number of oocytes obtained in fresh embryo transplantation, and pretreatment with GnRHa could also increase the success rate of in vitro fertilization (IVF) before the frozen embryo transfer.

Key words: Endometriosis, Gonadotropin-releasing hormone, Infertility, female, Reproductive techniques, assisted, Pregnancy rate