Abstract: The Sirtuins family has been one of the research hotspots in recent years. Sirtuins were involved in multiple biological processes including metabolism, gene expression, oxidative stress and cellular aging. SIRT3, a member of the Sirtuins family, plays an important role in protecting cells from damage by antioxidation. The deacetylation of SIRT3 in mitochondria is most active, regulating ROS production and clearance, ATP production and mitochondrial function through various molecular mechanisms. As one of the key factors regulating ROS production, SIRT3 plays a fundamental role in the reproductive biological processes such as ovarian reserve, follicular development, oocyte meiosis, pre-implantation embryo development, oocyte aging and granulosa cells function. Therefore, SIRT3 can be a potential candidate target to develop some drugs for improving ovarian function. This article reviews the role of SIRT3 and possible molecular pathways in the reproductive system.

Key words: Sirtuins, SIRT3, Mitochondria, Oxidative stress, Fertility, Ovary