Potential Application of Tanshinone in the Treatment of Polycystic Ovary Syndrome and Mechanism

doi:10.12280/gjszjk.20240275

Abstract

Abstract:

Tanshinone is a type of compound extracted from the traditional Chinese medicine Salvia miltiorrhiza, and it has received considerable attention due to its anti-inflammatory, antioxidant, and anti-cancer properties. Recent studies have suggested that tanshinone holds potential value in the treatment of polycystic ovary syndrome(PCOS). Tanshinone may effectively improve the insulin resistance, abnormal lipid metabolism, hyperandrogenemia, and chronic low-grade inflammation in PCOS patients by regulating hormone balance, enhancing insulin sensitivity, and reducing inflammatory responses. In addition, tanshinone can also improve ovulation disorders and ovarian dysfunction in PCOS patients. This article aims to review the research progress of tanshinone in the treatment of PCOS in recent years, in order to provide a theoretical reference for clinical practice and new drug development for PCOS.

Key words: Tanshinone, Polycystic ovary syndrome, Mechanism of action, Cryptotanshinone, Tanshinon ⅡA

LI An-qi, ZHU Meng-yi, WANG Yu, GAO Jing-shu, WU Xiao-ke. Potential Application of Tanshinone in the Treatment of Polycystic Ovary Syndrome and Mechanism[J]. Journal of International Reproductive Health/Family Planning, 2024, 43(6): 494-500.

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