Abstract: Vitamin D acts not only as a vitamin but also as a hormone. It is a sterol derivative that regulates calcium and phosphorus metabolism. Vitamin D can play some biological roles in cardiovascular diseases, immune regulation, anti-inflammatory, cancer and reproduction. The biological effects of vitamin D are usually mediated by the soluble protein, vitamin D receptor (VDR). VDR is a transcription factor located in the nucleus of target cells distributed in various human systems and tissues, including the female reproductive system. Recently, the relationship between vitamin D and the female reproduction attracted more and more attention. Vitamin D affects ovarian physiological function and female fertility to a certain extent, and is associated with some female reproductive diseases, such as polycystic ovary syndrome, pre-eclampsia, endometriosis, and gestational diabetes. The relationship between vitamin D deficiency and female reproductive system is briefly discussed in this review.

Key words: Vitamin D, Vitamin D Deficiency, Fertility, Female urogenital diseases and pregnancy complications, Vitamin D receptor