Abstract: Placental chorioangioma is the most common non-trophoblast and hamartoma-like tumor originating in the capillaries or larger vessels. The general prognosis of the small volume is good, and the morbidity is estimated to be 1% of all deliveries. The placental hemangioma with a diameter of more than 4 cm should be given close attention, because the overloaded circulation could damage the fetus. In rare cases, the giant placental hemangioma with a diameter of more than 4.0-5.0 cm can directly influence the fetal circulation and cause neonatal cerebral infarction. In this paper, we report a case of the giant placental hemangioma with a size of about 6.0 cm×5.0 cm and the combined neonatal cerebral infarction. Both the giant placental hemangioma and the neonatal cerebral infarction of unknown causes are rare, suggesting that the placental examination should be regarded as an important diagnostic test in those cases of neonatal cerebral infarction of unknown causes.

Key words: Placenta, Hemangioma, Chorion, Brain infarction, Infant, newborn, Case reports