Abstract: Objective: To investigate the effect of cervical conization on the pregnancy outcome of in vitro fertilization and embryo transfer (IVF-ET) in patients with infertility. Methods：A total of 35 infertile patients with a history of cervical conization who treated with IVF-ET from January 2013 to December 2019 were selected as the case group, and 98 infertile patients without history of cervical conization and with the results of normal or inflammatory cervical curettage who treated with IVF-ET in the same period were randomly selected as the control group. The index of early pregnancy and the delivery outcome of singleton delivery were compared between the two groups. Results：There were no significant differences in age, years of infertility, times of pregnancy, parity and factors of infertility between the two groups (P＞0.05). There was no significant differences in the abortion rate and early abortion rate between the two groups (P＞0.05), but the cervical ligature rate in the study group was higher than that in the control group (P=0.001). There were no significant differences in term delivery, premature delivery, gestational age, cesarean section and low birth weight between the two groups (all P＞0.05), but the birth weight of newborns in the study group was significantly lower than that in the control group (P=0.048). Conclusions：The history of cervical conization has no significant effect on the pregnancy outcome of infertile patients undergoing IVF-ET. We can reduce the occurrence of obstetrical complications and obtain better pregnancy outcome by transferring single embryo, checking cervical function in early pregnancy and controlling body weight during pregnancy.

Key words: Conization of cervix uteri;, Reproductive techniques, assisted, Fertilization in vitro;, Embryo transfer;, Pregnancy outcome