Abstract: Objective: To investigate the factors of fetal death in the third trimester of pregnancy, and to discuss the matters needing attention and the effective intervention, in order to reduce the incidence of the perinatal fetal death. Methods：From January 1, 2011 to December 31, 2018, there were 128 cases of fetal death in the third trimester of pregnancy in the obstetrics department of Hebei General Hospital, including 110 cases of the age-appropriate women (aged 20-35 years) and 18 cases of the aged group (aged ≥35 years). And there were 114 cases of single pregnancy and 14 cases of twin pregnancy. The clinical data were retrospectively analyzed. Results：The main causes of fetal death in 114 cases of single pregnancy included gestational hypertension (34/114, 29.8%), umbilical cord-related factors (19/114, 16.7%), placenta or fetal membrane-related factors (16/114, 14.0%), and amniotic fluid-related factors (15/114, 13.2%). The proportion of fetal death due to the placenta- or fetal membrane-related factors in the full-term birth group was higher than that in the preterm group (25% vs. 9%, P＜0.05). The main cause of 14 cases of twin pregnancy and fetal death is the related complications of the single chorionic double amniotic sac twin pregnancy (6/14, 42.9%). Conclusions：It is possible to reduce the incidence of fetal death by the comprehensive measures, such as regular prenatal exam, to determine the chorionic status of twin pregnancy as early as possible, to detect, diagnose and treat pregnancy complications as early as possible, and to terminate pregnancy timely in high-risk pregnancy.

Key words: Fetal death；, Pregnancy trimester, third；, Hypertension, pregnancy-induced；, Age groups；, Risk factors