Abstract: Ovarian cancer is one of the most lethal gynecological cancers. The development of useful biomarkers for the diagnosis and prognosis of ovarian cancer is essential for new targeted therapies and prolonging the survival time. Long non-coding RNAs (lncRNAs) , a kind of non-coding transcripts which have been emerging recently, are involved in the occurrence and development of various diseases. Some LncRNAs have been proved to play a key functional role in ovarian cancer, which is the basis of targeted therapy of individualized drugs. In this article, the basic structure, function, localization and classification of lncRNAs, as well as the research methods, were summarized, and the relationship between the different expression patterns of lncRNAs in ovarian cancer and the proliferation, differentiation, invasion and treatment response of ovarian cancer cells was expounded. In addition, the potential value of lncRNAs as a therapeutic target for ovarian cancer, so as to improve chemotherapy resistance, was also discussed.

Key words: RNA, long noncoding；, Ovarian neoplasms；, Cell proliferation；, Cell differentiation；, Therapy