Abstract: Polycystic ovary syndrome (PCOS) is a common clinical reproductive endocrine disease, and the incidence increases year by year. The pathogenesis of PCOS is related to many factors, in which the genetic factor may play a key role. Long non-coding RNA (lncRNA) refers to a kind of RNAs whose length exceeds 200 nucleotides. Although lncRNAs do not participate in the translation of protein, the activites of lncRNAs and the changes of activities are closely related to the growth and development, cell proliferation, differentiation and apoptosis. More and more studies have shown that lncRNAs are related to the pathogenesis of PCOS. lncRNAs may play some roles in the sex hormone secretion, insulin resistance, follicular development, granulosa cell proliferation and apoptosis, suggesting that lncRNAs almost participate in all aspects of PCOS development. This article reviews the recent research progress of lncRNAs in the pathogenesis of PCOS, to provide new ideas for the diagnosis and treatment of PCOS.

Key words: Polycystic ovary syndrome；, RNA, long noncoding；, Insulin resistance；, Granulosa cells；, Ovarian follicle