Animal Model of Premature Ovarian Insufficiency

doi:10.12280/gjszjk.20200406

Abstract

Abstract:

The childbearing time of woman has been postponed and the willingness decreased, with a large trend. However, female fertility decrease is earlier than the body physiological senescence, and ovarian reserve remarkably declines from the age of 35. Premature ovarian inscufficiency (POI) is a clinical syndrome of decreased ovarian function before the age of 40, which is characterized by menstrual disorder with high gonadotropin and low estrogen level. It is true that POI affects the physical and mental health of women. At present, the mechanism of POI is not clear. The POI animal model is the basis of the research, and the preparation ways of different models are different. This article reviews the preparation methods, characteristics and judgment criteria of common rodent animal models of POI, such as the models of immune, chemoradiotherapy, continuous ovarian stimulation, D-galactose induction and gene editing. These models provide practical tools for researchers to explore the pathogenesis of POI and to develop new therapeutic ways.

Key words: Primary ovarian insufficiency, Model,animal, Chemoradiotherapy, Genes, Ovulation induction

FU Yu-jie, SUN Xiao-yan, ZHANG Xue-hong. Animal Model of Premature Ovarian Insufficiency[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(2): 131-136.

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