Research Progress of m6A Modification in Reproductive-Related Diseases

doi:10.12280/gjszjk.20230145

Abstract

Abstract:

N⁶-methyladenosine (m⁶A) methylation is the most common RNA modification in eukaryotes, which regulates gene expression and biological functions by controlling RNA metabolism, alternative splicing, degradation and translation. In recent years, it has been found that m⁶A methylation plays an important regulatory role in the reproductive system, and that m⁶A is involved in the occurrence and development of polycystic ovary syndrome, endometriosis, premature ovarian insufficiency, adenomyosis and other female reproductive endocrine diseases and female reproductive system tumors. In addition, m⁶A methylation modification can also regulate human spermatogenesis and testicular function, and m⁶A is associated with male oligoasthenospermia and male reproductive system tumors. Taken together, m⁶A methylation modification may be a new target for the regulation of reproductive-related diseases. In this article, we review the mechanism of m⁶A methylation modification and the research progress in reproductive-related diseases, which has certain guiding significance for the diagnosis and treatment of reproductive-related diseases.

Key words: N⁶-methyladenosine, Methylation, Genital diseases, female, Urogenital neoplasms, Spermatogenesis

ZHOU Xin-yue, ZHANG An-ni, ZHANG Xue-hong. Research Progress of m⁶A Modification in Reproductive-Related Diseases[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(5): 392-397.

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Research Progress of m⁶A Modification in Reproductive-Related Diseases

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