Advances in Clinical Diagnosis and Treatment of Premature Ovarian Insufficiency

doi:10.12280/gjszjk.20200169

Abstract

Abstract:

Premature ovarian insufficiency (POI) is characterized by the decline of ovarian function before the age of 40 years, with severe influence on the physical and mental health of women of childbearing age. The etiology of most POIs remains unclear, which currently includes genetic factors, immunological factors and iatrogenic factors. POI patients have the reduced fertility. It is not enough to improve symptoms by hormone replacement therapy (HRT). However, there is no effective treatment so far, especially in terms of fertility preservation. In recent years, assisted reproductive technology has provided certain treatments for POI patients with fertility needs. In addition, the frozen ovarian tissue transplantation and stem cell transplantation may be the new options. This review will describe the progress of clinical diagnosis and treatment of POI.

Key words: Primary ovarian insufficiency, Fertility, Estrogen replacement therapy, Reproductive techniques,assisted, Stem cell transplantation

CHENG Ming, JIA Chan-wei, LIU Ying. Advances in Clinical Diagnosis and Treatment of Premature Ovarian Insufficiency[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(2): 137-141.

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