Pathogenic Factors and Management Strategies of Treatment-Resistant Thin Endometrium

doi:10.12280/gjszjk.20210037

Abstract

Abstract:

Endometrial receptivity is one of the main factors affecting embryo implantation rate, and endometrial thickness is an important index to evaluate endometrial receptivity. Patients with thin endometrium (TE) have poor clinical pregnancy outcome. The endometrium of most TE patients can reach a suitable thickness required for embryo implantation after estrogen treatment. However, some of TE patients cannot reach suitable thickness even though giving super-physiological dose of estrogen, which is called treatment-resistant thin endometrium (TTE). The pathogenesis of TTE is not clear. It is believed that the related factors of TTE are the insensitivity to estrogen receptor, abnormal expression of related factors and insufficient intimal blood supply. The main causes of TTE include infection, uterine cavity operation and insufficient blood flow. The causes of some patients with TTE are still unknown. At present, the clinical treatment of TTE mainly includes drug treatment, regenerative medicine and traditional Chinese medicine. Although there are a variety of treatment methods for TTE, the efficiency is still not satisfactory. This article reviews the epidemiology, high risk factors and treatment of TTE in order to provide reference for clinical treatment.

Key words: Endometrium, Receptor, estrogen, Vascular endothelial growth factors, Matrix metalloproteinase 11, Reproduction technique, assisted, Therapy

WANG Li-yan, FU Xiao-qian, LI Hua, YANG Yi-hua. Pathogenic Factors and Management Strategies of Treatment-Resistant Thin Endometrium[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(4): 314-318.

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