Abstract:

Thyroid autoantibodies may be associated with the increased risk of miscarriage, but whether there is a causal relationship and the related mechanism is not clear. The effect of thyroid autoimmunity (TAI) on the outcomes of assisted reproduction is a controversial topic for a long time. Existing studies have shown that the evidence of levothyroxine, glucocorticoid, immunoglobulin and so on, using to improve the outcomes of assisted reproduction in TAI women is insufficiency. It is needed to study further in future. The causal relationship between thyroid autoantibodies and adverse pregnancy should be further explored. In the research design, thyroid autoantibody titer, different insemination methods and fresh embryo transfer or frozen embryo transfer should be considered. It is necessary to further study whether intracytoplasmic sperm injection/frozen embryo transfer（ICSI/FET） is more beneficial to the pregnancy outcomes of TAI women undergoing assisted reproduction.

Key words: Thyroiditis, autoimmune, Immunoglobulins, thyroid-stimulating, Reproductive techniques, assisted, Pregnancy outcome, Therapy, Thyroid autoimmunity, Thyroid autoantibodies