The Relationship between PI3K/Akt Autophagy Pathway and HIF-1α in HPV16 Related Cervical Cancer

doi:10.12280/gjszjk.20210613

Abstract

Abstract:

Almost 90% of cervical cancer has the high risk of human papilloma virus (HR-HPV) persistent infection. The risk of high-grade cervical intraepithelial neoplasia or cervical cancer can be further increased in patients with HPV16 persistent infection. Studies have shown that hypoxia exists in human tumors. Hypoxia-inducible factor-1α (HIF-1α) is closely related to hypoxia microenvironment. The activation of HIF-1α can promote tumor growth, which has become a research hotspot. The classic phosphatidylinositol 3-kinase (PI3K)/ protein kinase B (Akt) autophagy pathway inhibits autophagy, and the expression of this pathway is out of order in a variety of human tumors. Its abnormal activation makes abnormal cell proliferation and differentiation, which promotes the growth of tumor. This article reviews the different mechanisms of HPV16 infection that may cause the changes of HIF-1α and PI3K/Akt autophagy pathways, and their relationship in cervical cancer.

Key words: Uterine cervical neoplasms, Human papillomavirus 16, Hypoxia-inducible factor 1,alpha subunit, Phosphatidylinositol 3-kinases, Protein kinases, PI3K/Akt autophagy pathway

WU Tong-tong, WANG Zhi-lian. The Relationship between PI3K/Akt Autophagy Pathway and HIF-1α in HPV16 Related Cervical Cancer[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(2): 172-176.

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