Neutrophil Extracellular Traps and Related Reproductive Diseases

doi:10.12280/gjszjk.20200457

Abstract

Abstract:

Neutrophil extracellular traps (NETs) can be formed after the activation of neutrophils, which participate in the pathophysiological process of many diseases including related reproductive diseases. However, the specific pathogenesis has not been clarified. At present, studies have shown that the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and other cytokines play an important role in the formation process of NETs, and that many signaling pathways, such as protein tyrosine kinase (PTK) and phosphatidylinositol 3-kinase (PI3K), regulate the formation of NETs. Many reproductive diseases such as preeclampsia could be further explained by NETs. In this paper, we will review the formation of NETs and the related mechanisms.

Key words: Extracellular traps, NADP, Protein-tyrosine kinases, p38 mitogen-activated protein kinases, Mitogen-activated protein kinase 1, Pre-eclampsia, Neutrophil extracellular traps

QIAO Guo-dong, WANG Yong-hong. Neutrophil Extracellular Traps and Related Reproductive Diseases[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(3): 260-264.

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