Research Progress on Sperm DNA Damage in Assisted Reproductive Technology

doi:10.12280/gjszjk.20240471

Abstract

Abstract:

Sperm DNA integrity is essential for forming a fertilized egg, and sperm DNA damage may affect the success of assisted reproductive technology (ART). Sperm DNA damage consists mainly of single-stranded and double-stranded damage, which may affect the success of ART at multiple aspects, including fertilization, embryo quality and pregnancy. The causes of sperm DNA damage mainly include oxidative stress, age, hormones and environmental factors. Also, the ability of the oocyte to repair sperm DNA damage is critical. Currently, the clinical and laboratory efforts are focused on reducing the sperm DNA fragmentation index (DFI) through pharmacological interventions and optimizing sperm selection for ART treatment, to improve the clinical outcomes of ART. We review the research progress on sperm DNA damage, its impact on the outcomes of ART treatment, and possible improvement of semen preparation methods.

Key words: Spermatozoa, DNA damage, DNA fragmentation, Reproductive techniques, assisted, Infertility, male, Fertilization in vitro, Sperm injections, intracytoplasmic

XU Shan, MENG Jiang-ping. Research Progress on Sperm DNA Damage in Assisted Reproductive Technology[J]. Journal of International Reproductive Health/Family Planning, 2025, 44(1): 71-77.

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