Abstract: Objective：To compare the clinical efficacy of Mirena with the thermal balloon endometrial ablation for menorrhagia treatment. Methods： The well-known databases in both English and Chinese were retrieved. The randomized controlled trials of Mirena and the thermal balloon endometrial ablation were included after evaluating the quality of methodology. Revman 5.2 software was then used to do statistics. Results：There were not statistical differences in the effective rate, the failure rate and the patient satisfaction between two methods. The incidence of postoperative complications and the direct medical cost in the Mirena group were significantly lower than those in the thermal balloon endometrial ablation group （P＜0.05）. Conclusions：Mirena is safe and effective for patients with menorrhagia. Compared with the thermal balloon endometrial ablation, Mirena is a better alternative method as the conservative treatment for menorrhagia.

Key words: Menorrhagia, Levonorgestrel, Delayed-action preparations, Intrauterine devices, medicated, Endometrium, Meta-analysis