Abstract: Antimicrobial peptides are of important components of low-molecular weight peptides to defense organisms invasion. Antimicrobial peptides have many characteristics，such as the big antibacterial potential，broad antibacterial spectrum，safety，and non-toxic. Some of them also have powerful spermicidal and contraceptive potential. This review introduced the difunctionality of spermicide and microbicide of four antimicrobial peptides，including Magainin，Dermaseptins，Nisin and Subtilosin，which could provide us new ideas to develop the biological products with the difunctionality of spermicide and microbicide.

Key words: Anti-bacterial agents, Peptides, Spermatocidal agents, Contraceptive agents, male, Review