Abstract: Cadmium is a kind of toxic heavy metals and hazardous pollutant which affects many organs and systems, such as liver, kidney, lung, bones and reproductive system. The male reproductive system is more sensitive to cadmium toxicity than others. The decreased levels of StAR, P450scc, 3β-HSD and 17β-HSD caused by the cadmium exposure lead to the inhibition of steroidogenesis and the reduction of testosterone level. Cadmium exposure induces the apoptosis of germ cells and the ultrastructure changes of organelles, which ultimately damage the function of male reproductive system. The endocrine disorder, imbalance of oxidative stress and the over-activation of apoptotic factors play an important role in the mechanism of cadmium toxicity. Some antioxidants and anti-apoptotic drugs could reduce the toxicity of cadmium to some extent. This paper discusses the effect of cadmium on the male reproductive system, as well as the treatment of cadmium exposure.

Key words: Cadmium, Genital diseases, male, Apoptosis, Oxidative stress