Objective: To analyze the clinical and pathological characteristics of gastric-type adenocarcinoma (GAS), in order to diagnose and treat the disease early and improve the prognosis. Methods: The diagnosis, treatment, follow-up, pathological morphology, immunohistochemical characteristics and other data of 9 cases of cervical GAS in Tianjin Central Hospital of Gynecology Obstetrics from July 2013 to July 2017 were retrospectively analyzed, and relevant literatures were reviewed. Results: The median age of 9 patients was 44 years old. 6 patients were diagnosed in pre-operation, 2 in intra-operation and 1 was in post-operation. There were 3 cases of long-term abnormal vaginal discharge, 2 cases of intrauterine fluid and 5 cases of ovarian mass. The mean overall time to survival was 104.3 months (95%CI: 66.6-142.1 months). The survival rates at 12 months, 24 months and 36 months were 88.9%, 77.8% and 66.7% respectively. The cervical GAS mainly invaded towards the uterine body. The pathological microscope showed little difference from the normal gland. Immunohistochemical analysis of HIK1083, Mucin 6 (MUC6), cytokeratin7 (CK7), CDX2, villin, paired box gene-8 (PAX-8), CA-125, CA-19-9, P16 and carcinoembryonic antigen (CEA) showed high positive rates, while the positive rates of CK20, PAX-2 and P53 were low. Conclusions: Cervical GAS is rare and easy to be misdiagnosed. However, through the multidisciplinary combination of clinical, imaging and pathology, there is an opportunity to achieve the early diagnosis and treatment of GAS and improve the survival expectation.
