转化生长因子β1在宫腔粘连中的研究进展

doi:10.12280/gjszjk.20220466

摘要/Abstract

摘要：

宫腔粘连（intrauterine adhesion，IUA）的实质是子宫内膜基底层受损后引起的子宫内膜纤维化疾病。主要的临床表现有月经改变、不孕及妊娠丢失、反复的胚胎种植失败等，严重影响了育龄期妇女的生殖健康。IUA发生的分子机制较为复杂多样，是由多因素、多环节综合控制的。转化生长因子β1（transform growth factor-β1，TGF-β1）作为一类在调节细胞生长、分化、凋亡方面发挥重要作用的细胞因子，参与了人体多种疾病病理进展的重要环节。目前认为该细胞因子与组织纤维化密切相关，其过度表达会促进子宫内膜纤维化，加重IUA的程度。综述TGF-β1及其相关通路在IUA中的研究进展。

关键词: 转化生长因子β1, 子宫疾病, 纤维化, 炎症, 宫腔粘连, 发病机制

Abstract:

Intrauterine adhesion (IUA) is a disease of the endometrial fibrosis caused by the damaged endometrial basal layer. The common clinical manifestations of IUA are menstrual change，infertility and pregnancy failure and repeated embryo implantation failure. Therefore, IUA seriously affects the reproductive health of women of reproductive age. The evolution of IUA is more complex and variable, which is controlled by a multifactorial and multilevel combination. Transform growth factor-β1 (TGF-β1) as a cytokine plays an important role in regulating cell growth, differentiation and apoptosis. TGF-β1 is involved in the pathological progression of many human diseases. It is believed that TGF-β1 is closely related to the tissue fibrosis, and that its overexpression promotes the endometrial fibrosis and aggravates the degree of IUA. In this article, we describe the research progress of TGF-β1 and its related pathways in IUA.

Key words: Transforming growth factor beta1, Uterine diseases, Fibrosis, Inflammation, Intrauterine adhesions, Pathogenesis

李光璨, 翟超, 张晓轩, 任春娥. 转化生长因子β1在宫腔粘连中的研究进展[J]. 国际生殖健康/计划生育杂志, 2023, 42(1): 83-88.

LI Guang-can, ZHAI Chao, ZHANG Xiao-xuan, REN Chun-e. Research Progress of Transform Growth Factor-β1 in Intrauterine Adhesions[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(1): 83-88.

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