子宫内膜异位症与肠道菌群失衡关系的研究进展

doi:10.12280/gjszjk.20220468

摘要/Abstract

摘要：

子宫内膜异位症（endometriosis，EMs）是一种妇科常见的激素依赖性疾病，高发于育龄期女性。该病虽是一种良性疾病，但具有黏附、侵袭和转移等恶性肿瘤的性质，且容易反复发作，严重影响女性患者日常生活和身心健康。EMs具体发病机制尚不明确，但已有研究证明肠道菌群失衡在其发病过程中起重要作用。肠道菌群失衡影响EMs发病可能与参与免疫调控、脂多糖生成、影响炎症因子及血管生成素释放、参与性激素代谢等机制有关。综述目前对肠道菌群失衡参与EMs发病的相关途径及机制的最新研究进展。

关键词: 子宫内膜异位症, 胃肠道微生物组, 免疫, 诊断, 治疗

Abstract:

Endometriosis (EMs) is a common hormone-dependent disease in gynecology, which is most common in women of reproductive age. Although EMs is a benign disease, it has the properties of adhesion, invasion, metastasis and other malignant tumors, and it is prone to repeated attacks. EMs seriously affects the daily life and physical and mental health of female patients. The specific pathogenesis of EMs is still unclear. Many studies have demonstrated that the imbalance of intestinal flora plays an important role in the pathogenesis of EMs. The impact of intestinal flora imbalance on the pathogenesis of EMs may be related to the mechanisms involved in immune regulation, lipopolysaccharide generation, inflammatory factors and angiopoietin release, and sex hormone metabolism. In this review, the intestinal flora imbalance and mechanism related to the pathogenesis of EMs were summarized.

Key words: Endometriosis, Gastrointestinal microbiome, Immunity, Diagnosis, Therapy

张海霞, 冯晓玲. 子宫内膜异位症与肠道菌群失衡关系的研究进展[J]. 国际生殖健康/计划生育杂志, 2023, 42(1): 66-71.

ZHANG Hai-xia, FENG Xiao-ling. Research Progress on the Relationship between Endometriosis and Intestinal Flora Imbalance[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(1): 66-71.

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