脑源性神经营养因子与女性生殖的相关性研究进展

doi:10.12280/gjszjk.20220501

摘要/Abstract

摘要：

脑源性神经营养因子（brain-derived neurotrophic factor，BDNF）是神经营养因子家族的一员，与其受体结合后，在神经元的发育和分化中起着重要作用。近年研究发现，BDNF还在女性生殖系统中表达，在女性生殖内分泌中起着重要的作用。在卵巢中，BDNF具有促进卵泡发育、卵母细胞生长成熟和排卵等作用；在子宫中，BDNF能通过促进子宫内膜的增殖、调节子宫内膜容受性，使其更易适应胚胎的植入，还能促进胚胎及胎盘发育。且BDNF表达异常又与多囊卵巢综合征、卵巢储备功能下降和子宫内膜异位症等疾病有着密切的关系。因此，关于BDNF在生殖系统中的表达、对生殖功能的影响及其与生殖相关疾病发生发展的关系可能成为新的研究方向。综述近年国内外关于BDNF与女性生殖功能及相关疾病的研究，为改善女性生殖功能和治疗相关疾病提供一定的参考。

关键词: 脑源性神经营养因子, 卵泡, 多囊卵巢综合征, 卵巢储备功能, 子宫内膜异位症

Abstract:

Brain-derived neurotrophic factor (BDNF) is a member of the family of neurotrophic factors. When combined with its receptors, BDNF plays an important role in the development and differentiation of neurons. Recent studies have found that BDNF is also expressed in the female reproductive system and plays an important role in female reproductive endocrine. In the ovary, BDNF can promote follicle development, oocyte growth and maturation, ovulation and so on. In the utero, BDNF can regulate the endometrial receptivity by promoting endometrial proliferation, making it easier to adapt to embryo implantation, and promoting embryo and placenta development. The abnormal expression of BDNF is closely related to the occurrence of polycystic ovary syndrome, diminished ovarian reserve, endometriosis and other diseases. Therefore, it is of great significance to study the expression of BDNF in the reproductive system, its influence on reproductive function and the correlation with the reproduction-related diseases. In this paper, we summarize the reports on BDNF and female reproductive function and the related diseases, so as to provide a certain reference for improving female reproductive function and treating the related diseases.

Key words: Brain-derived neurotrophic factor, Ovarian follicle, Polycystic ovary syndrome, Ovarian reserve, Endometriosis

朱文彬, 许婧余, 马瑞红, 夏天, 栾祖乾. 脑源性神经营养因子与女性生殖的相关性研究进展[J]. 国际生殖健康/计划生育杂志, 2023, 42(2): 140-144.

ZHU Wen-bin, XU Jing-yu, MA Rui-hong, XIA Tian, LUAN Zu-qian. Research Progress of Brain-Derived Neurotrophic Factor and Female Reproduction[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(2): 140-144.

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