组织蛋白酶L在卵母细胞和早期胚胎发育中的作用

doi:10.12280/gjszjk.20250442

摘要/Abstract

摘要：

组织蛋白酶L（cathepsin L，CTSL）是溶酶体半胱氨酸蛋白酶家族的核心成员，通过降解细胞外基质调控原始卵泡激活与排卵过程。其N-糖基化修饰的CTSL变体通过破坏线粒体功能、加剧氧化应激和干扰纺锤体组装，成为驱动卵母细胞质量下降的关键介质。CTSL异常表达还与生殖衰老密切相关。在胚胎发育层面，CTSL参与母源-合子转变、自噬调控和表观遗传重编程等关键事件，其活性动态精确地指导着早期胚胎发育进程。深入解析CTSL在雌性生殖调控网络中的作用，可增进对生殖细胞发育机制的理解，并有望应用于改善辅助生殖结局。

关键词: 组织蛋白酶L, 卵母细胞, 胚胎发育, 排卵, 后成说，遗传

Abstract:

Cathepsin L (CTSL), a pivotal member of the lysosomal cysteine protease family, participates in the regulation of primordial follicle activation and ovulation by degrading extracellular matrix. The N-glycosylated CTSL variants emerge as key mediators driving oocyte quality deterioration by compromising mitochondrial function, amplifying oxidative stress, and disrupting spindle assembly. The aberrant expression of CTSL is intimately linked to reproductive aging. At the level of embryonic development, CTSL participates in fundamental biological events including maternal-to-zygotic transition, autophagy regulation and epigenetic reprogramming, suggesting that the dynamic activation of CTSL precisely directs early embryogenesis. The in-depth analysis of the roles of CTSL in the female reproductive regulatory network will enhance the understanding of the development mechanism of germ cells, which is expected to be applied in the clinical practice to improve the outcomes of assisted reproduction.

Key words: Cathepsin L, Oocytes, Embryonic development, Ovulation, Epigenesis, genetic

朱青, 宋佳, 唐淮云. 组织蛋白酶L在卵母细胞和早期胚胎发育中的作用[J]. 国际生殖健康/计划生育杂志, 2026, 45(1): 49-53.

ZHU Qing, SONG Jia, TANG Huai-yun. The Role of Cathepsin L in Oocyte and Early Embryonic Development[J]. Journal of International Reproductive Health/Family Planning, 2026, 45(1): 49-53.

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