国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2010, Vol. 29 ›› Issue (1): 11-14.

• 综述 • 上一篇    下一篇

微小RNA和生殖

郭婧综述,董旻岳审校

  

  1. 浙江大学医学院附属妇产科医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-01-15 发布日期:2010-01-15
  • 通讯作者: 董旻岳

MicroRNA and Reproduction

GUO Jing;DONG Min-yue   

  1. Women’s Hospital School of Medicine Zhejiang University
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-01-15 Online:2010-01-15
  • Contact: DONG Min-yue

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摘要： 微小RNA（microRNA）是一种长度约19~25 nt的非编码RNA，通过碱基互补配对与mRNA的3’非翻译区结合降解靶基因或抑制其翻译，进行转录后负调控。迄今，上千种microRNA得到成功鉴定。microRNA不但在细胞的增殖、分化、凋亡、组织更新和干细胞分化过程中发挥作用，且参与生殖细胞发育、成熟和胚胎早期发育、激素分泌等生殖调节。

关键词: MicroRNA, 基因表达调控, 生殖, 胚胎发育

Abstract: microRNA, a class of noncoding RNA of approximately 19-25 nucleotides, which can regulate gene expression by binding to the region of 3’ UTR of the target mRNAs to degrade or suppress target genes, is a post-transcriptional regulation. At present, thousands of microRNAs have been identified successfully. It is demonstrated that microRNA play an important role in cellular proliferation and apoptosis, self-renewal, stem cell differentiation, as well as in the development of germ cell and embryo, the regulation of hormone secretion.

Key words: microRNA, Gene expression regulation, Reproduction, Embryonic development