国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2010, Vol. 29 ›› Issue (2): 105-108.

• 综述 • 上一篇    下一篇

抗苗勒管激素与多囊卵巢综合征

罗晓燕;王蕊   

  1. 610041成都，四川大学华西第二医院妇产科（罗晓燕），首都医科大学附属北京天坛医院（王蕊）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-03-15 发布日期:2010-03-15

Study of Anti-mullerian Hormone and Polycystic Ovary Syndrome

LUO Xiao-yan;WANG Rui   

  1. Departmentof Obstetrics and Gynecology，West China Second University Hospital，Sichuan University，Chengdu 610041，China（LUO Xiao-yan）；Beijing Tiantan Hospital of Capital Medical University，Beijing 100050, China（WANGRui）
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-03-15 Online:2010-03-15

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摘要： 抗苗勒管激素（AMH）是唯一从初级卵泡到窦卵泡期由颗粒细胞产生的一种激素。AMH
与卵泡发育、卵巢储备功能及围绝经期的预测均有很强的相关性，能有效评估辅助生殖技术的结果。因证实其能抑制卵巢始基卵泡的募集和卵泡刺激素（FSH）诱导的卵泡生长而逐渐引起重视。近年AMH 与多囊卵巢综合征（PCOS）相关性日益得到重视，AMH 与PCOS 关系的研究有助于对PCOS 发病机制的理解，并可能对PCOS 诊断及治疗效果评估有一定意义。

关键词: 抗苗勒管激素, 多囊卵巢综合征, 卵泡发育, 胰岛素抵抗, 二甲双胍

Abstract: Anti-mulerian hormone （AMH）is produced in the ovary by the granulose cells（GC）surrounding preantral and small antral follicles stage. AMH can be used for assessing ovarian reserve,predicting peri-menopausal period，and involving folliculogenesis. It also can be used for evaluating the effect
of ART. It has been suggested that AMH would inhibit the initiation of primordial follicle growth and FSH-
induced follicle growth. In recent years, the correlation between AMH and PCOS became important. It maybehelp to explain pathogenesy and assess diagnostic efficacy and therapeutic efficacy in PCOS patient.

Key words: Anti-mullerian hormone, Polycystic Ovary Syndrome, Folliculogenesis, Insulinresistance, Meformin