国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2010, Vol. 29 ›› Issue (2): 96-98.

• 综述 • 上一篇    下一篇

肥胖与妊娠期糖尿病关系的研究进展

吕晓娟;陈丹青   

  1. 310022 杭州，浙江省肿瘤医院（吕晓娟），浙江大学医学院附属妇产科医院（陈丹青）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-03-15 发布日期:2010-03-15

Relationship Between Maternal Obesity and Gestational Diabetes Mellitus

LV Xiao-juan;CHEN Dan-qing   

  1. Department of Gynecologic Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China（LV Xiao-juan）; Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China（CHEN Dan-qing）
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-03-15 Online:2010-03-15

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摘要： 妊娠期糖尿病（GDM）是妊娠期间首次发生或发现的糖代谢异常。研究表明，妊娠期间脂肪细胞因子分泌异常导致胰岛素抵抗增加可能是GDM 的发病机制。肥胖是GDM 发病的高危因素，且妊娠前肥胖、妊娠期体质量增长过多对围生结局产生不利影响，增加子痫前期、巨大儿、难产等并发症的发生率。有过GDM 史的妇女产后发生2 型糖尿病的风险明显增加，其子代远期也更容易发生肥胖和糖代谢紊乱。综述近年有关肥胖与GDM 的研究进展。

关键词: 妊娠期糖尿病, 胰岛素抵抗, 肥胖, 围生结局

Abstract: Gestational diabetes mellitus（GDM）is defined as glucose intolerance of various degrees that is first detected during pregnancy and developed from progressive insulin resistance that begins near mid-pregnancy which maybe associated with increased secretion of adipocytokine. Most studies recently reveal that
obesity is a risk factor of developing GDM and perinatal outcomes will be influenced by materal body mass index and weight gain during pregnancy. Women with GDM are at high risk for progressing to diabetes after pregnancy and their offspring also are more likely to developing obesity and abnormal glucose metabolism.

Key words: Gestational diabetes mellitus, Insulin resistance, Obesity, Perinatal outcomes