国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2010, Vol. 29 ›› Issue (2): 99-101.

• 综述 • 上一篇    下一篇

性激素结合球蛋白与胰岛素抵抗研究进展

姜文英;陈丹青   

  1. 310016 杭州市第一人民医院（姜文英）；浙江大学医学院附属妇产科医院（陈丹青）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-03-15 发布日期:2010-03-15

The Advance in the Study on SHBG and Insulin Resistant

JIANG Wen-ying;CHEN Dan-qing   

  1. Departmentof Gynaecology and Obstetrics，the First People’s Hospital，Hangzhou 310016，China （JIANG Wen-ing）；Wamen’s Hospital，School of Medicine, Zhejiang University, Hangzhou 310006, China（CHEN Dan-ing）
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-03-15 Online:2010-03-15

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摘要： 性激素结合球蛋白（SHBG）是由肝脏产生的一种糖蛋白，结合循环中的性激素。SHBG 结
合、转运血中大部分有生物活性的雄激素和雌激素并调节这些激素进入靶器官。SHBG 是通过胰岛素下调的，可反映胰岛素抵抗状态。SHBG水平随年龄、生理周期有一定变化，其与胰岛素抵抗的关系在不同人群中有差异。SHBG 与以胰岛素抵抗为特征的疾病（如糖尿病、多囊卵巢综合征、代谢综合征）有一定的相关性。

关键词: 性激素结合球蛋白, 岛素抵抗, 尿病, 囊卵巢综合征, 代谢综合征

Abstract: Sex hormone binding globulin（SHBG）is a glycoprotein secreted by the liver that binds sex
steroids in the circulation. In humans，SHBG binds and transports the biologically most important androgens
and estrogens in the blood，and regulates the access of these steroids to their targets tissues. The SHBG is
down-egulated by insulin and low SHBG level is associated with insulin resistant. SHBG concentration is
changed by age and menstrual cycles，and the relationship of SHBG and insulin resistant is different in
people. SHBG has a association with a variety of insulin resistant conditions including diabetes mellitus，
polycystic ovary syndrome and metabolis syndrome.

Key words: Sex hormone binding globulin, nsulin resistant, Diabetes mellitus, Polycystic ovarysyndrome, Metabolis syndrome