国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2010, Vol. 29 ›› Issue (6): 457-460.

• 综述 • 上一篇    下一篇

T细胞抗原受体γδT细胞与母胎免疫耐受

范登轩,金莉萍,李大金

  

  1. 200011 上海，复旦大学附属妇产科医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-11-15 发布日期:2010-11-15
  • 通讯作者: 金莉萍,李大金

TCRγδT Cells and the Maternal-Fetal Immune Tolerance

FAN Deng-xuan, JIN Li-ping, LI Da-jin   

  1. The Obstetrics and Gynecology Hospital of Fudan University，Shanghai 200011，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-11-15 Online:2010-11-15
  • Contact: JIN Li-ping,LI Da-jin,

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摘要： 母-胎界面是胚胎和母体直接接触的部位，母体和胚胎之间发生着复杂的对话，细胞、细
胞因子及细胞外基质之间构成相互作用的复杂网路，形成了母- 胎界面上特有的免疫耐受状态，以维持
正常妊娠。T细胞抗原受体酌啄T 细胞作为T 细胞的一个特殊亚群，主要分布在黏膜和上皮组织，是机体的
一种重要的免疫细胞，以非主要组织相容性复合体（MHC）限制性的方式识别各种抗原，在黏膜免疫中发
挥重要作用。母- 胎界面上的T 细胞抗原受体（TCR）酌啄T 细胞对母-胎免疫耐受状态的维持起重要作
用，与正常妊娠及复发性自发性流产均有着密切的关系。

关键词: 受体, 抗原, T 细胞, γ鄄δ, 母体胎儿间交换, 免疫耐受, 妊娠, 流产, 自然

Abstract: Maternal鄄fetal interface is the position that mother makes direct contact with her fetus.
There are complex crosstalks between the mother and the fetus. The complicated network among cells,
cytokines and extra鄄cellular matrix forms a specific state of maternal鄄fetal immune tolerance, which maintains
normal pregnancy. As a specific subset of T cells, TCR酌啄T cell is an important kind of immune cells residing
in mucosal and epithelial tissues. TCR酌啄T cells play a role in mucosal immunity. TCR酌啄T cells at maternal鄄
fetal interface have important implications for maintaining maternal鄄fetal immune tolerance. Hence, TCR酌啄T
cells are highly relevant with normal pregnancy and recurrent spontaneous abortion（RSA）.

Key words: Receptors, antigen, T-Cell, gamma-delta, Maternal-fetal exchange, Immunme tolerance, Pregnancy, Abortion, spontaneous